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Indeed, it is known that hydrochlorothiazide can target several ion transporters and enzymes including SLC4A8 , a Na + -dependent Cl − /HCO 3 − exchanger (NDCBE), SLC26A4 , a Na + -independent Cl − /HCO 3 − exchanger (Pendrin) and carbonic anhydrases (Pickkers et al., 1999

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